Review about differences in activation of G-protein coupled receptors

In "fast forward" publication in the Journal of Pharmacology and Experimental Therapeutics Urban et. al review the different effects of agonist and antagonists on GPCRs which are different from the current view of receptor activation. There are more groups of ligands (antagonists, agonists, inverse agonist and partial agonists) but they differ in their activation of second messenger systems.


Highly recommended:
http://dx.doi.org/10.1124/jpet.106.104463