Tuesday, July 11, 2006

Fun with 1-methyl cyclohexenes and cyclic terpnes

Tertiary allylic alcohols are easily rearranged and oxidised to alpha,beta-unsaturated ketones



1. Dauben, W.G. and D.M. Michno, Direct oxidation of tertiary allylic alcohols
A simple and effective method for alkylative carbonyl transposition. Journal of Organic Chemistry, 1977. 42(4): p. 682-685.



Selective ring opening of carene epoxides




Deagostino, et al., J. Chem. Soc., Perkin Trans. 1, 2001, 2856–2860


Saturday, July 01, 2006

Review about differences in activation of G-protein coupled receptors

In "fast forward" publication in the Journal of Pharmacology and Experimental Therapeutics Urban et. al review the different effects of agonist and antagonists on GPCRs which are different from the current view of receptor activation. There are more groups of ligands (antagonists, agonists, inverse agonist and partial agonists) but they differ in their activation of second messenger systems.


Highly recommended:
http://dx.doi.org/10.1124/jpet.106.104463

Collection of scanned articles

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